Buy Linaclotide Online ((EXCLUSIVE))
What is Linzess used for? Linzess prescription medication contains the active ingredient linaclotide and belongs to a class of medications known as guanylate cyclase-C agonists and is a 14-amino acid peptide. Linzess is used in the management of constipation in adults with chronic idiopathic constipation and irritable bowel syndrome with constipation - somewhat similar to dicyclomine (Bentyl). Linzess, along with some of its metabolites, bind to the surface of the intestines, resulting in metabolic changes which increase the secretion of chloride and bicarbonate into the intestinal lumen. Through these secretions, Linzess is thought to increase transit of fluids in the intestines and reduce pain. Following administration, the systemic availability of Linzess is low and plasma concentrations of Linzess are not measurable. Some drug is excreted in the stool.
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Linzess capsules are beads in hard gelatin. Linzess capsules are orally administered and come in Linzess 145 mcg and Linzess 290 mcg capsules. Linzess 145 mcg capsules and Linzess 290 mcg capsules are white to off-white opaque hard gelatin capsules. Linzess is expensive, costing approximately $15 per Linzess 145 mcg capsule when one is paying out of pocket for the medication. Linzess coupons may be available at times online or from the manufacturer. Linzess capsules should be stored at 25 C.
Linzess is a prescription medication in the US. For this reason, one cannot simply buy Linzess online or get Linzess OTC (over the counter) from a pharmacy without first consulting a licensed medical provider and obtaining a prescription. However, people who might need a Linzess medication prescription can connect with a licensed medical provider through Push Health who can prescribe Linzess medication, including Linzess capsules, when appropriate to do so.
*Maximum savings limit applies; patient out-of-pocket expense may vary. This offer is available to patients with commercial prescription insurance coverage for a valid prescription of LINZESS (linaclotide) at the time the prescription is filled by the pharmacist and dispensed to the patient. Offer not valid for patients enrolled in Medicare, Medicaid, or other federal or state healthcare programs. Please see Program Terms, Conditions, Privacy Notice, and Eligibility Criteria.
This medication must not be used in children younger than 6 years because of the risk of serious side effects. Before taking linaclotide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
For elderly patients, although no dose adjustment is required the treatment should be carefully monitored and periodically re-assessedLinzess is contraindicated for patients with known or suspected mechanical gastrointestinal obstruction.Should prolonged (e.g. more than 1 week) or severe diarrhoea occur, medical advice should be sought and temporary discontinuation of linaclotide until diarrhoea episode is resolved may be considered.
Linaclotide is an agonist of guanylate cyclase-C (GC-C). Once linaclotide and its active metabolite binds to GC-C, it has local effect on the luminal surface of the intestinal epithelium. Activation of GC-C by linaclotide results in the intra- and extracellular increase of cyclic guanosine monophosphate concentrations (cGMP). This elevation of cGMP levels stimulates the secretion of chloride and bicarbonate into the intestinal lumen via activation of cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. Ultimately, linaclotide helps patients with IBS (especially with constipation) as GI transit is accelerated and the release of intestinal fluid is increased. In animal models, a decrease in visceral pain after administration of linaclotide may be observed. A decrease in the activity of pain-sensing nerves occurs as a result of an increase in extracellular cGMP.
Linaclotide is metabolized within the gastrointestinal tract to its principal, active metabolite, MM-419447, by loss of the terminal tyrosine moiety. Both linaclotide and the metabolite are proteolytically degraded within the intestinal lumen to smaller peptides and naturally occurring amino acids.
Introduction: These post hoc analyses provide clinically relevant data concerning time to response for individual irritable bowel syndrome with constipation (IBS-C) symptoms after linaclotide use.
Discussion: Although treatment responses with linaclotide occurred in >50% of patients with IBS-C within 4 weeks of treatment initiation, benefits for individual abdominal symptoms and/or CSBM frequency can still occur between 4 and 12 weeks. A lack of improvement in one symptom does not negate the possibility of response for others, highlighting the importance of discussing all symptoms with patients and not assuming treatment futility at 4 weeks.
Linaclotide may cause life-threatening dehydration in young laboratory mice. Children younger than 6 years of age should never take linaclotide. Children 6 to 17 years of age should not take linaclotide.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with linaclotide and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( ) or the manufacturer's website to obtain the Medication Guide.
Linaclotide comes as a capsule to take by mouth. It is usually taken once a day on an empty stomach, at least thirty minutes before the first meal of the day. Take linaclotide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take linaclotide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Linaclotide controls the symptoms of IBS-C and CIC, but does not cure these conditions. Your constipation symptoms may improve in 1 week, and it may take slightly longer for your stomach pain to improve. Continue to take linaclotide even if you feel well. Do not stop taking linaclotide without talking to your doctor. If you stop taking linaclotide, your symptoms may return in about 1 week.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( ) or by phone (1-800-332-1088).
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
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Clients will need a prescription to buy Linaclotide from Kiwi Drug. If you don't have one, you may want to take advantage of our online doctor services---simply answer the questions provided during checkout to see if you qualify. There is no extra charge for our online doctor services.
Linzess contains the ingredient linaclotide. It is categorized in a drug class called guanylate cyclase-C agonists. Linzess works by increasing the movement of food and waste through the intestines. In animal studies, Linzess also decreased abdominal pain.
Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Linzess. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication.
Although appropriate studies on the relationship of age to the effects of linaclotide have not been performed in the geriatric population, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving this medicine.
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Legal disclaimer: The FDA, due to the current state of their regulations, has taken the position that virtually all shipments of prescription drugs imported from a Canadian online pharmacy by a U.S. consumer will violate the law. However, many legal experts disagree with the FDA's position in this regard stating that such importation is permitted under certain federal and state laws. Several State governments and consumer rights groups actively promote the importation of medications. The FDA itself provides the public information on how to import medications safely. Furthermore, there is no record of any US individual being prosecuted by the FDA for importing non-controlled prescription drugs for their personal use.
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Each capsule contains 290 micrograms of linaclotide. The active substance in Constella, linaclotide, attaches to some receptors in the gut called guanylate cyclase C. By attaching to these receptors, it reduces pain and increases the secretion of fluid into the gut, thereby loosening the stools and increasing bowel movements. 041b061a72